Breast cancer is one of the most common malignant tumors around the world, although there are several treatments for breast cancer, it is known as the second cause of cancer deaths among women. Despite progress in diagnosis and treatment, cancer is one of the leading causes of death in the world. In addition to genetic and environmental factors, epigenetic factors also contribute to etiology of cancer. Recently, it has been found that miRNA (a group of non-coding small RNAs) are closely related to various diseases, including cancer. miRNA regulate gene expression in eukaryotes by inhibiting mRNA translocation or mRNA degradation through targeting relative maturation with the 3rd end of the (3 UTR) target mRNA. Due to the potential of miRNA in targeting a large number of mRNAs (group of 19-25 oligonucleotides) are involved in almost all biological phenomena including cell cycle regulation, cell growth, apoptosis, cellular differentiation, and response to stress. Increasing level of evidences suggest that miRNA plays an important role in the biology of cancer, and recent studies have confirmed the oncogenic and tumor inhibitory role of miRNA in cancer cells. In addition, they have shown that the expression of these miRNA can be regulated by tumor inhibitors and oncogenes. The expression of miRNA both in in-vitro and in-vivo may also be regulated through the synthesis of pre-miRNA molecules or antisense oligonucleotides, which can be promising perspective for cancer treatment.
According to the latest report of the Mazandaran Province Lifeguard Board in Iran, the number of sea drownings this year, despite the COVID-19 method, is equal to the same period last year. Statistics that not only show the ineffectiveness of warnings about compliance with health protocols but shows disregard for the standards of presentation and swimming in the beach waters of the Caspian Sea. On the beach, tiny droplets from sneezing and coughing can spread even further, as these spots are usually windy. Therefore, in such a situation, you should more distant from others. The speed of movement of these tiny particles in the air decreases very quickly, but the wind can move them over long distances. Something that happens to marine viruses.
The cartographic cum site-effectuated view of Shillong region of northeast India is presented here. Starting from the existing tectonics, the prevalent geological settings of the study area is comprehensively delineated. The seismic prone area is further overviewed in the context of site effects with accompaniment of available borehole information. The resonance frequency estimates form ambient noise survey along with receiver functions are outlined which implicates a heterogeneous subsurface. This further helps in segregating the region into two compelling profiles, thereby enabling us to get a deeper insight in the probable subsurface as well as heterogeneity. Eventually, the influence of topography over strata was also highlighted and interpreted as well.
Heavy metals pollution in soil, water and environment pose a huge risk to human health and wellbeing. Most often they are non-biodegradable which leads to accumulation and enters into the ecosystem and food chain thereby it affects water, vegetation and aqueous systems. The conventional physiochemical methods are not environment friendly and they do suffer with several setbacks. Alternatively bioremediation of toxic heavy metals using natural sources is safer, efficient, rapid, environment friendly and no secondary compound formation. Microbial bioremediation mechanisms such as oxidation/ reduction, biosorption, biominerilisation, biotransformation, bioaccumulation, bioprecipitation, biocrystalisation, bioleaching or biomining, bioaugumentation, biofilm formation, production of biosurfactants and immobilization with nanoparticles have huge potential for effective clean-up of the toxic heavy metals pollution. This review highlights the recent updates in bioremediation of heavy metals through biodegradation methods. The future aspects of bioremediation processes for effective degradation, removal and management of heavy metals pollution are also discussed.
Abstract\nRecent studies have shown that Chest radiographic (CXR) and chest computed tomography (CT) scans have been used to diagnose coronavirus (COVID-19) disease as an important counterpart to the reverse transcription polymerase chain reaction (RT-PCR) diagnostic protocol. This work explores the application of CXR and CT scans as diagnostic instruments for COVID-19. Numerous databases were searched for COVID-19 articles which documented the clinical features of CXR and CT scans. The documented cases based on the evaluation of the imaging characteristics Chest radiographic findings may be confirmed with the most basic CT scans. Peripheral, bilateral and primary ground-glass distortion are the most prominent CT results with COVID-19 infections. In addition, the use of special and ambiguous terms such as pneumonia, blurred opacities, airspace disease, patchy opacities and infiltrates makes it difficult to clearly perceive the different chest radiographic findings.
Abstract\nThis study investigates the radiation shielding capacity of fly ash geopolymer (FAGP) as a viable alternative to conventionally used ordinary Portland cement (OPC) due to the high demand for an environmentally friendly, cost effective and non-toxic shield material. The FAGP material was fabricated and combined with Barium sulphate (BaSO4) at different ratios (0, 5, 10 and 15%). Different thicknesses (3, 6 and 9 cm) of the samples were also prepared. Energy-dispersive X-ray (EDX) was used to determine the elemental percentages of the materials, which were then used to calculate their effective atomic number (Zeff). The ion chamber was used to detect the dose of radiation transmitted through the samples. The lowest radiation dosage (34.68 µGy) and highest Zeff was achieved with FAGP combined with 15% BaSO4 at 9 cm thickness. The decrease in radiation dosage can be attributed to the increase in Zeff with the addition of BaSO4 to FAGP, which in turn increases the density of FAGP. Thus, radiation dose can be significantly reduced with a higher ratio of BaSO4 to FAGP. This study shows that FAGP combined with BaSO4 is a promising radiation shielding material, as well as a viable alternative to OPC.
Black soils out of INBS criteria are evaluated in this contribution. Limited indicators of black soils out of INBS criteria are depth of humus horizon less than 25 cm where the soil properties are practically the same as in black soils using the INBS criteria (represented by Chernozems and Phaeozems) and other special group of black soils with low soil reaction (pH/H2O < 5.5 and pH/KCl < 5.0), low base saturation (< 50 %) with high content of SOM (10 – 20 %) represented mostly by Andosols in conditions of Slovakia.\n\nThe 1-st group of black soils out of INBS criteria is mostly situated on arable land (belongs to the most fertile soils – Chernozems and Phaeozems) and the 2-nd group of black soils is mostly situated in mountains on some volcanic rocks (Andosols) in Slovakia. Total area of these soils is about 8.7 % of soil cover in Slovakia.
The demands of wireless communication systems are continuously growing as users are increasing day-by-day. In our modern society, high data-rate, very low power consumption transmitter, simple transmitter and receiver, and very high quality of services are mostly needed. To meet above-mentioned demands massive multiple input multiple output (MIMO) is the only technology which may cater this demand as this technology is equipped with a large amount of base station (BS) antennas at the transmitter. It is only promising technology to offer higher data-rate in large coverage. It recently drew more researcher attention as of its huge system performance. In it, the large number of BS antennas all together work at the same spectrum resource. With a very large amount of BS antennas, MIMO is serving fully adaptively and coherently. In massive MIMO, the extra antennas help the system to cover the signal energy into ever smaller coverage area. When using joint antenna and user selection and scheduling in massive MIMO which improve system performance and energy efficiency. In this system, when BS antennas reach an infinite number, the additive noise and user interference tends to zero. In a massive MIMO system, it is very hard to achieve channel state information (CSI) to fulfill the demands of the user. In this paper the potential and how this technology is serving the 5G and future wireless communication system are presented in detail.